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Breast Cancer
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:Breast Cancer をテンプレートにして作成
開始行:
#norelated
#contents
* BC overview
Breast cancer is a malignantized breast duct epithelium s...
The main symptoms are hard lumps that can occur in the br...
** Breast cancer type
Breast cancer is roughly divided into three types - "noni...
*** Noninvasive cancer
It is an early cancer staying inside the duct or in the l...
*** Invasive cancer
It means that it extends to the outside of ducts and leaf...
*** Paget's disease
Paget's disease is a special type of breast cancer spread...
Eczema, redness and erosion of the papilla become clues f...
** Triple negative breast cancer (TNBC)
Three (triple) estrogen receptor · progesterone receptor ...
Female hormones estrogen and progesterone are factors rel...
[[HER2]] is a cancer gene, and when [[HER2]] is expressed...
Triple negative breast cancer (TNBC) is generally said to...
Symptoms
*** Breast lump
Breast cancer becomes about 1 cm from about 5 mm, you wil...
There is no pain first.
- Change in breast skin
When breast cancer occurs near the skin of the breast, th...
*** papillary secretions
When cancer cells reach the papilla, secretions mixed wit...
Noninvasive cancer has increased subjective symptoms such...
*** Depression of the nipple and depression of the breast
It may appear by cancer reaching the breast's skin or nea...
*** Inflammatory Breast Cancer
Although no obvious lump can be found, the skin on the br...
Inflammatory breast cancer is a pathological condition th...
*** Paget's disease
Eradication of the nipple and eczema of the surrounding s...
*** Swollen lymph nodes near the breast
When metastasizing to lymph nodes near the breast, the ly...
*** Symptoms of distant metastasis
The symptoms are different depending on the metastasized ...
Bone metastasis is suspected when waist, back, shoulder p...
In case of pulmonary metastasis, coughing may occur or br...
Metastasis of the liver is less likely to cause symptoms,...
** Cause
Relationship with estrogen, a female hormone, is preemine...
*** Main risk factors of breast cancer
- Menarche age is young
- Long period from menarche to menopause
- Elderly first-age (or no birth history / lactation hist...
- Obesity after menopause
- I have a benign breast disease
- Families (especially mother and sister) have become bre...
- Heavy weight at birth
- Long-term enforcement of hormone replacement therapy (c...
- Exposure to radiation
-smoking
- night work
- High intake of alcohol
** Diagnostic test
*** X-ray shooting (mammography)
Mammography is an examination in which breasts are sandwi...
Small cancers that can not be found by palpation may be f...
At this time, if cancer is suspected, there may be a lump...
Even with these symptoms, not everything is malignant.
- Shooting method
Standing in front of the device barely upper body bare, p...
--Sensitivity is said to decrease when breast tissue is l...
*** 3D mammography
Mammography (2D - MMG) compresses the breast and takes pi...
For postmenopausal patients, it is easier to understand b...
In 3D mammography (3D-MMG), images are picked up from a p...
- It is effective for the following patients.
-- For young people with thick breast tissue
-- Those who were considered precision inspections with m...
-- Worried person of local recurrence after breast cancer...
*** Breast ultrasonography (echo)
Lie on your back on the examination table, apply jelly to...
During the examination, the examination room will be dark...
*** Automated Breast Ultrasound System (AUBS)
Scan the entire breast like a copy and inspect the breast...
It is a device that can express images like CT and MRI be...
The inspection data can be saved temporarily and review c...
**** Dense Breast
In the case of dense breasts, ultrasonic examination (ech...
For women with high mammary gland density in breasts, bre...
*** Breast Magnetic Resonance Imaging (MRI)
Mammary gland MRI examination is an examination that imag...
- Gadolinium contrast medium
Compared to iodinated contrast agents, the incidence of s...
MRI inspection has the advantage that you can adjust the ...
- Shooting method
Remove metallic objects such as accessories from the body...
-- Fast spin echo method (FSE method)
After photographing the T1 weighted image (fat is white a...
-- Take T1 emphasized images with the contrast agent whil...
*** CT (computed tomography)
It is a special X-ray tomography system that uses a compu...
*** Bone Scintigraphy
It is an exam for examining the transfer of breast cancer...
It is often done when it is judged that the possibility o...
*** Positron mammography (PEM)
It is based on the principle of positron emission tomogra...
**** Positron emission tomography (PET) inspection
I inject a radioactive test drug that cancer cells take m...
*** puncture aspiration cytology
Puncture Aspiration cytology is a method of ultrasound gu...
There is a little bit of pain as it stabs the needle, but...
Cytodiagnosis is often done to estimate whether it is ben...
*** secretion fine herpes
The secretion solution from the nipple (nipple) is taken ...
*** Needle biopsy (biopsy)
It is an examination to investigate the cause of the symp...
Needle biopsy is divided into core needle biopsy and aspi...
**** Core needle biopsy / puncture needle aspiration inha...
It is a method of inserting a thick needle (usually 14 ga...
**** Suction type breast tissue biopsy / mammotome biopsy...
If palpation can not find a clear lump and abnormality is...
Multiple large pieces of tissue can be collected with one...
It is possible to perform biopsy of microcalcification fo...
*** Inspection of distant metastasis
There are lungs, liver, bones, lymph nodes, etc. as dista...
To diagnose whether there is distant metastasis, chest ra...
**** sentinel lymph node biopsy
Sentinel lymph node biopsy is a method to investigate whe...
Sentinel lymph nodes (watch-around lymph nodes) are lymph...
In other words, if there is no metastasis in this sentine...
If you find this sentinel lymph node before surgery and y...
** stage
When the diagnosis of breast cancer arrives, it is examin...
It is classified into 5 stages of clinical stages largely...
-Stage 0
It remains in the mammary gland where breast cancer occur...
-Stage I
The size of the lump is less than 2 cm (the size of 1 yen...
-Stage II
It is divided into stage IIa and stage IIb.
-- IIa stage
when the size of the lump is less than 2 cm, there is met...
-- IIb stage
when the size of the lump is 2 to 5 cm and there is metas...
-Stage III
It is called "locally advanced breast cancer" and it is d...
-- stage IIIa
There is a metastasis in the lymph nodes under the armpit...
-- stage IIIb
Regardless of the size of the lump or the presence or abs...
-- stage IIIc
Regardless of the size of the lump, there is metastasis t...
-Stage IV
It is a case where it is spreading to a remote organ. Bre...
Recurrent breast cancer The fact that breast cancer occur...
It usually refers to what occurs in other organs (metasta...
**Treatment
For the treatment of breast cancer, we first measure the ...
As a result, for example, if the type of cancer that the ...
Surgical therapy and radiotherapy are "local therapy" whi...
*** Surgical Therapy
I will do it to resect the cancers made in the breast. We...
**** Tumor nuclear surgery
It is an operation to resect only breast lump. Aspiration...
If you strongly suspect cancer, you should resect about 1...
**** partial breast excision
It is a method of resecting a part of the breast includin...
Depending on the site and spread of the lesion, it is cut...
Included in this are breast sector partial resection to r...
If the lump is large, when breast cancer is spreading wit...
We usually irradiate after surgery to prevent recurrence ...
**** Breast simple resection
I will remove all breasts on the cancer side and do not r...
**** Pectoral muscle preserving mastectomy
I will resect the lymph nodes under the breast and armpit...
There are two things: Petty surgery that leaves only the ...
**** Pectoral muscle combined mastectomy (Halstead method)
Besides breast and underarm lymph nodes, remove the large...
**** Axillary lymph node dissection (surgery for lymph no...
Axillary lymph node dissection prevents lymph node recurr...
- Side effects of axillary lymph node dissection
Lymphedema (swelling) may appear on the arm on the side o...
**** sentinel lymph node biopsy
Sentinel lymph nodes are found by injecting radioisotopes...
In many cases, the lymph nodes under the armpit will be s...
**** subcutaneous mammary total cure
Total chemotherapy with subcutaneous mammary gland leaves...
As with preserving surgery, survival rate is the same eve...
**** Skin Sparing Surgery
I leave the skin and totally pick out the nipple / isola ...
**** breast reconstruction surgery
It is an operation to form breasts lost by surgery to rem...
For details, please refer to the page of breast reconstru...
*** Radiation therapy
Radiation has the effect of killing cancer cells. In brea...
- Radiation side effects
It also occurs by irradiation of normal tissues around th...
Specific side effects will appear depending on the irradi...
*** Accelerated breast partial irradiation method (APBI)
Without applying radiation to the entire breast, concentr...
Pass the iridium (brachytherapy) radiation material 1 mm ...
Operate with the equipment and irradiate partial irradiat...
During treatment, stay in the hospital and stab the tube ...
-cost
If you include public health insurance, including hospita...
*** Hormonal therapy
Drugs used to treat breast cancer are roughly divided int...
There are individual differences in drug therapy, but lar...
Hormone receptor (estrogen receptor and progesterone rece...
Breast cancer susceptible to female hormones is called "h...
- On female hormones
In women with menstruation and active ovarian function, t...
**** Hormone therapy drugs
Antiestrogens, selective aromatase inhibitors, luteinizin...
Side effects of hormonal therapy are generally characteri...
***** Antiestrogen agent
- Norvadex tablets, Tasuomin tablets (generic name: tamox...
It is used for breast cancer surgery and for metastatic b...
It inhibits the binding of female hormones to the estroge...
- side effects
When used for a long time, there is a risk of uterine can...
***** Selective aromatase inhibitor (AI)
Treatment of hormone receptor positive postmenopausal bre...
- Femara tablet (generic name: letrozole)
- Aromasin tablets (generic name: exemestane)
- Arimidex tablets (generic name: Anastrozole)
Combined administration with anti [[HER2]] monoclonal ant...
-- side effects
Since bone mass decreases, ingenuity to make good use of ...
--- Actonel tablet (generic name: risedronate sodium hydr...
--- Fosamak tablets (generic name: sodium alendronate hyd...
--- Benet Tablets (generic name: Risedronate sodium hydra...
--- Bonaron tablets (generic name: sodium alendronate hyd...
--- Dyron 'nel tablet (common name: disodium disodium eti...
***** Gonadotropic hormone secretion inhibitor
- For Leupline Injection (generic name: leuprorelin)
Leuplin inhibits secretion of gonadotropin. Therefore, it...
Leuplin is a set of powder and liquid, if you inject both...
-- side effects
Hot flashes, hot feeling, hot flashes, stiff shoulders, h...
Liver dysfunction, decreased libido, emotional instabilit...
Jaundice, ulcer, depression, etc.
***** Progesterone (luteinizing hormone) secretion stimul...
In the premenopausal case, we suppress the secretion of f...
*** Chemotherapy (anti-cancer drug)
Chemotherapy has the effect of working on various stages ...
While chemotherapy kills cancer cells, it also acts on no...
Chemotherapy includes injections and internal medicine. D...
**** Main anti-cancer drugs
Representative anticancer drugs used for breast cancer in...
C
- Endox tablet (generic name: cyclophosphamide) alkylatin...
M
- Methotrexate tablets (generic name: methotrexate) Antim...
F
-5-FU tablet (generic name: 5-fluorouracil) anti-metabolite
A
- For Adriacine Note (Generic name: Adriamycin) Anthracyc...
E
- Forarmorubicin injection (generic name: epirubicin hydr...
T
- Taxotere for intravenous infusion (generic name: doceta...
- Taxol injection (generic name: paclitaxel)
- Abraxane for intravenous infusion (generic name: paclit...
***** combination therapy
-CMF therapy
Combine cyclophosphamide, methotrexate, fluorouracil. I d...
-CAF therapy
It is a combination of cyclophosphamide, doxorubicin, flu...
-AC therapy
It is a combination of cyclophosphamide and doxorubicin.
-CEF therapy
It is a combination of cyclophosphamide, epirubicin, fluo...
**** Other anticancer agents
- Yufuti Capsule (generic name: Tegafur / Urashil)
It is an anticancer drug whose hair can not escape. It is...
*** Molecular targeted therapy
It is a treatment with a drug that specifically acts only...
**** Herceptin treatment
20% to 30% of breast cancers have a lot of proteins calle...
Herceptin treatment is applied only to cancer with metast...
- For Herceptin Injection (generic name: trastuzumab mole...
-- side effects
Nausea, headaches, fatigue, etc. may also appear, but the...
-- Serious side effects
There are reports of interstitial pneumonia, bone marrow ...
*** Bone metastasis treatment
When breast cancer metastasizes to bone, there may be cas...
Bisphosphonate preparations and denosumab are drugs that ...
- Poria subcutaneous injection syringe (generic name: den...
終了行:
#norelated
#contents
* BC overview
Breast cancer is a malignantized breast duct epithelium s...
The main symptoms are hard lumps that can occur in the br...
** Breast cancer type
Breast cancer is roughly divided into three types - "noni...
*** Noninvasive cancer
It is an early cancer staying inside the duct or in the l...
*** Invasive cancer
It means that it extends to the outside of ducts and leaf...
*** Paget's disease
Paget's disease is a special type of breast cancer spread...
Eczema, redness and erosion of the papilla become clues f...
** Triple negative breast cancer (TNBC)
Three (triple) estrogen receptor · progesterone receptor ...
Female hormones estrogen and progesterone are factors rel...
[[HER2]] is a cancer gene, and when [[HER2]] is expressed...
Triple negative breast cancer (TNBC) is generally said to...
Symptoms
*** Breast lump
Breast cancer becomes about 1 cm from about 5 mm, you wil...
There is no pain first.
- Change in breast skin
When breast cancer occurs near the skin of the breast, th...
*** papillary secretions
When cancer cells reach the papilla, secretions mixed wit...
Noninvasive cancer has increased subjective symptoms such...
*** Depression of the nipple and depression of the breast
It may appear by cancer reaching the breast's skin or nea...
*** Inflammatory Breast Cancer
Although no obvious lump can be found, the skin on the br...
Inflammatory breast cancer is a pathological condition th...
*** Paget's disease
Eradication of the nipple and eczema of the surrounding s...
*** Swollen lymph nodes near the breast
When metastasizing to lymph nodes near the breast, the ly...
*** Symptoms of distant metastasis
The symptoms are different depending on the metastasized ...
Bone metastasis is suspected when waist, back, shoulder p...
In case of pulmonary metastasis, coughing may occur or br...
Metastasis of the liver is less likely to cause symptoms,...
** Cause
Relationship with estrogen, a female hormone, is preemine...
*** Main risk factors of breast cancer
- Menarche age is young
- Long period from menarche to menopause
- Elderly first-age (or no birth history / lactation hist...
- Obesity after menopause
- I have a benign breast disease
- Families (especially mother and sister) have become bre...
- Heavy weight at birth
- Long-term enforcement of hormone replacement therapy (c...
- Exposure to radiation
-smoking
- night work
- High intake of alcohol
** Diagnostic test
*** X-ray shooting (mammography)
Mammography is an examination in which breasts are sandwi...
Small cancers that can not be found by palpation may be f...
At this time, if cancer is suspected, there may be a lump...
Even with these symptoms, not everything is malignant.
- Shooting method
Standing in front of the device barely upper body bare, p...
--Sensitivity is said to decrease when breast tissue is l...
*** 3D mammography
Mammography (2D - MMG) compresses the breast and takes pi...
For postmenopausal patients, it is easier to understand b...
In 3D mammography (3D-MMG), images are picked up from a p...
- It is effective for the following patients.
-- For young people with thick breast tissue
-- Those who were considered precision inspections with m...
-- Worried person of local recurrence after breast cancer...
*** Breast ultrasonography (echo)
Lie on your back on the examination table, apply jelly to...
During the examination, the examination room will be dark...
*** Automated Breast Ultrasound System (AUBS)
Scan the entire breast like a copy and inspect the breast...
It is a device that can express images like CT and MRI be...
The inspection data can be saved temporarily and review c...
**** Dense Breast
In the case of dense breasts, ultrasonic examination (ech...
For women with high mammary gland density in breasts, bre...
*** Breast Magnetic Resonance Imaging (MRI)
Mammary gland MRI examination is an examination that imag...
- Gadolinium contrast medium
Compared to iodinated contrast agents, the incidence of s...
MRI inspection has the advantage that you can adjust the ...
- Shooting method
Remove metallic objects such as accessories from the body...
-- Fast spin echo method (FSE method)
After photographing the T1 weighted image (fat is white a...
-- Take T1 emphasized images with the contrast agent whil...
*** CT (computed tomography)
It is a special X-ray tomography system that uses a compu...
*** Bone Scintigraphy
It is an exam for examining the transfer of breast cancer...
It is often done when it is judged that the possibility o...
*** Positron mammography (PEM)
It is based on the principle of positron emission tomogra...
**** Positron emission tomography (PET) inspection
I inject a radioactive test drug that cancer cells take m...
*** puncture aspiration cytology
Puncture Aspiration cytology is a method of ultrasound gu...
There is a little bit of pain as it stabs the needle, but...
Cytodiagnosis is often done to estimate whether it is ben...
*** secretion fine herpes
The secretion solution from the nipple (nipple) is taken ...
*** Needle biopsy (biopsy)
It is an examination to investigate the cause of the symp...
Needle biopsy is divided into core needle biopsy and aspi...
**** Core needle biopsy / puncture needle aspiration inha...
It is a method of inserting a thick needle (usually 14 ga...
**** Suction type breast tissue biopsy / mammotome biopsy...
If palpation can not find a clear lump and abnormality is...
Multiple large pieces of tissue can be collected with one...
It is possible to perform biopsy of microcalcification fo...
*** Inspection of distant metastasis
There are lungs, liver, bones, lymph nodes, etc. as dista...
To diagnose whether there is distant metastasis, chest ra...
**** sentinel lymph node biopsy
Sentinel lymph node biopsy is a method to investigate whe...
Sentinel lymph nodes (watch-around lymph nodes) are lymph...
In other words, if there is no metastasis in this sentine...
If you find this sentinel lymph node before surgery and y...
** stage
When the diagnosis of breast cancer arrives, it is examin...
It is classified into 5 stages of clinical stages largely...
-Stage 0
It remains in the mammary gland where breast cancer occur...
-Stage I
The size of the lump is less than 2 cm (the size of 1 yen...
-Stage II
It is divided into stage IIa and stage IIb.
-- IIa stage
when the size of the lump is less than 2 cm, there is met...
-- IIb stage
when the size of the lump is 2 to 5 cm and there is metas...
-Stage III
It is called "locally advanced breast cancer" and it is d...
-- stage IIIa
There is a metastasis in the lymph nodes under the armpit...
-- stage IIIb
Regardless of the size of the lump or the presence or abs...
-- stage IIIc
Regardless of the size of the lump, there is metastasis t...
-Stage IV
It is a case where it is spreading to a remote organ. Bre...
Recurrent breast cancer The fact that breast cancer occur...
It usually refers to what occurs in other organs (metasta...
**Treatment
For the treatment of breast cancer, we first measure the ...
As a result, for example, if the type of cancer that the ...
Surgical therapy and radiotherapy are "local therapy" whi...
*** Surgical Therapy
I will do it to resect the cancers made in the breast. We...
**** Tumor nuclear surgery
It is an operation to resect only breast lump. Aspiration...
If you strongly suspect cancer, you should resect about 1...
**** partial breast excision
It is a method of resecting a part of the breast includin...
Depending on the site and spread of the lesion, it is cut...
Included in this are breast sector partial resection to r...
If the lump is large, when breast cancer is spreading wit...
We usually irradiate after surgery to prevent recurrence ...
**** Breast simple resection
I will remove all breasts on the cancer side and do not r...
**** Pectoral muscle preserving mastectomy
I will resect the lymph nodes under the breast and armpit...
There are two things: Petty surgery that leaves only the ...
**** Pectoral muscle combined mastectomy (Halstead method)
Besides breast and underarm lymph nodes, remove the large...
**** Axillary lymph node dissection (surgery for lymph no...
Axillary lymph node dissection prevents lymph node recurr...
- Side effects of axillary lymph node dissection
Lymphedema (swelling) may appear on the arm on the side o...
**** sentinel lymph node biopsy
Sentinel lymph nodes are found by injecting radioisotopes...
In many cases, the lymph nodes under the armpit will be s...
**** subcutaneous mammary total cure
Total chemotherapy with subcutaneous mammary gland leaves...
As with preserving surgery, survival rate is the same eve...
**** Skin Sparing Surgery
I leave the skin and totally pick out the nipple / isola ...
**** breast reconstruction surgery
It is an operation to form breasts lost by surgery to rem...
For details, please refer to the page of breast reconstru...
*** Radiation therapy
Radiation has the effect of killing cancer cells. In brea...
- Radiation side effects
It also occurs by irradiation of normal tissues around th...
Specific side effects will appear depending on the irradi...
*** Accelerated breast partial irradiation method (APBI)
Without applying radiation to the entire breast, concentr...
Pass the iridium (brachytherapy) radiation material 1 mm ...
Operate with the equipment and irradiate partial irradiat...
During treatment, stay in the hospital and stab the tube ...
-cost
If you include public health insurance, including hospita...
*** Hormonal therapy
Drugs used to treat breast cancer are roughly divided int...
There are individual differences in drug therapy, but lar...
Hormone receptor (estrogen receptor and progesterone rece...
Breast cancer susceptible to female hormones is called "h...
- On female hormones
In women with menstruation and active ovarian function, t...
**** Hormone therapy drugs
Antiestrogens, selective aromatase inhibitors, luteinizin...
Side effects of hormonal therapy are generally characteri...
***** Antiestrogen agent
- Norvadex tablets, Tasuomin tablets (generic name: tamox...
It is used for breast cancer surgery and for metastatic b...
It inhibits the binding of female hormones to the estroge...
- side effects
When used for a long time, there is a risk of uterine can...
***** Selective aromatase inhibitor (AI)
Treatment of hormone receptor positive postmenopausal bre...
- Femara tablet (generic name: letrozole)
- Aromasin tablets (generic name: exemestane)
- Arimidex tablets (generic name: Anastrozole)
Combined administration with anti [[HER2]] monoclonal ant...
-- side effects
Since bone mass decreases, ingenuity to make good use of ...
--- Actonel tablet (generic name: risedronate sodium hydr...
--- Fosamak tablets (generic name: sodium alendronate hyd...
--- Benet Tablets (generic name: Risedronate sodium hydra...
--- Bonaron tablets (generic name: sodium alendronate hyd...
--- Dyron 'nel tablet (common name: disodium disodium eti...
***** Gonadotropic hormone secretion inhibitor
- For Leupline Injection (generic name: leuprorelin)
Leuplin inhibits secretion of gonadotropin. Therefore, it...
Leuplin is a set of powder and liquid, if you inject both...
-- side effects
Hot flashes, hot feeling, hot flashes, stiff shoulders, h...
Liver dysfunction, decreased libido, emotional instabilit...
Jaundice, ulcer, depression, etc.
***** Progesterone (luteinizing hormone) secretion stimul...
In the premenopausal case, we suppress the secretion of f...
*** Chemotherapy (anti-cancer drug)
Chemotherapy has the effect of working on various stages ...
While chemotherapy kills cancer cells, it also acts on no...
Chemotherapy includes injections and internal medicine. D...
**** Main anti-cancer drugs
Representative anticancer drugs used for breast cancer in...
C
- Endox tablet (generic name: cyclophosphamide) alkylatin...
M
- Methotrexate tablets (generic name: methotrexate) Antim...
F
-5-FU tablet (generic name: 5-fluorouracil) anti-metabolite
A
- For Adriacine Note (Generic name: Adriamycin) Anthracyc...
E
- Forarmorubicin injection (generic name: epirubicin hydr...
T
- Taxotere for intravenous infusion (generic name: doceta...
- Taxol injection (generic name: paclitaxel)
- Abraxane for intravenous infusion (generic name: paclit...
***** combination therapy
-CMF therapy
Combine cyclophosphamide, methotrexate, fluorouracil. I d...
-CAF therapy
It is a combination of cyclophosphamide, doxorubicin, flu...
-AC therapy
It is a combination of cyclophosphamide and doxorubicin.
-CEF therapy
It is a combination of cyclophosphamide, epirubicin, fluo...
**** Other anticancer agents
- Yufuti Capsule (generic name: Tegafur / Urashil)
It is an anticancer drug whose hair can not escape. It is...
*** Molecular targeted therapy
It is a treatment with a drug that specifically acts only...
**** Herceptin treatment
20% to 30% of breast cancers have a lot of proteins calle...
Herceptin treatment is applied only to cancer with metast...
- For Herceptin Injection (generic name: trastuzumab mole...
-- side effects
Nausea, headaches, fatigue, etc. may also appear, but the...
-- Serious side effects
There are reports of interstitial pneumonia, bone marrow ...
*** Bone metastasis treatment
When breast cancer metastasizes to bone, there may be cas...
Bisphosphonate preparations and denosumab are drugs that ...
- Poria subcutaneous injection syringe (generic name: den...
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